In order to study the treatment of groundwater waste filtrate pollution under complex red bed geological conditions, by introducing groundwater quality oxidation recovery technology, the treatment effect of waste filtrate pollution under different dosage of oxidant was studied, and the three-dimensional analysis of groundwater pollution was carried out by indoor 3D-EEM. The results of site pollution treatment show that sodium persulfate has obvious oxidation effect on filtrate in complex laterite layer. The removal efficiency of COD and insoluble substances first increases and then decreases with the increase of sodium sulfate input. The relationship between the effect of groundwater pollution remediation and input is approximately parabolic. Sodium persulfate has good treatment effect in groundwater remediation of red-bed landfill site. The results show that the optimal input of sodium persulfate is 2.0 g/L and the degree of groundwater remediation is 66.74%.