Zhuhai City is a semi-central city in Guangdong Province. In order to meet the requirement of “Outline Development Plan for the Guangdong-Hong Kong-Macao Greater Bay Area”, and construct the system of water resources guarantee in Zhuhai-Macao with high-quality, strategy research of water resources guarantee of Zhuhai has vast importance. Focus on the long-term target of population reaching 5 million and GDP reaching ￥2 trillion of Zhuhai, four different scenarios were set up to analyze the water resources carrying status and adaptability of water resources guarantee of Zhuhai, based on water conservation, high efficiency, Macao Guarantee, started from water demand forecasting and pollutants discharged forecasting. The results show that water quantity is the major factor of water resources carrying status of Zhuhai in the further and key element of water resources guarantee is water safety. Strategies of water resources to supporting socioeconomic development were designed, for quality growth guarantee of Zhuhai City.